Mouthwash to prevent mouth sores from Datopotamab deruxtecan
Treatments studied
Part of Cancer, Lungs & breathing, Skin clinical trials.
This trial tests if a dexamethasone mouthwash can prevent painful mouth sores (stomatitis) caused by the cancer drug Datopotamab deruxtecan (Dato-DXd). It's for people with certain types of advanced lung or breast cancer who have already tried other treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced non-small cell lung cancer (non-squamous) that got worse after at least one prior treatment, OR advanced triple-negative breast cancer that got worse after at least one prior treatment, OR advanced hormone receptor-positive breast cancer that got worse after hormonal therapy (including a CDK4/6 inhibitor) and one prior chemotherapy or antibody-drug conjugate.
- You are 18 years or older.
- You are able to take care of yourself (up and about more than half of waking hours).
- Your heart pumps at least 50% blood per beat (normal function).
- You have tumors that can be measured on scans (RECIST 1.1).
- Your blood counts and organ function are good enough for this treatment, as checked by your doctor.
- You agree to use effective birth control during and for 7 months (women) or 4 months (men) after the last dose.
- You are willing to self-report any mouth pain and keep a diary of mouth symptoms.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a steroid mouthwash can prevent mouth sores caused by the drug Datopotamab Deruxtecan (Dato-DXd). It is for people with certain types of advanced breast cancer or lung cancer who are about to start Dato-DXd for the first time.
This trial tests if using a steroid mouthwash can prevent painful mouth sores caused by certain chemotherapy drugs. It aims to help patients who are starting or already receiving chemotherapy known to cause mouth sores.
This trial tests a new drug, datopotamab deruxtecan, against a standard chemotherapy (docetaxel) for people with advanced non-squamous lung cancer that has gotten worse after previous treatment. It is for those who do not have certain genetic changes (like EGFR, ALK, or ROS1) and whose tumors have a protein called TROP2.
This trial tests whether sucking on ice (oral cryotherapy) during a specific type of chemo called TROP2-ADC can prevent or reduce painful mouth sores in people with advanced breast cancer. If you're starting this treatment for the first time, you may be able to join.
This trial studies Dato-DXd (an antibody-drug medicine) in people with triple-negative breast cancer that has spread to the brain. It aims to see how well it controls brain tumors when they are newly found or growing after other treatments.
This trial tests a new drug called datopotamab deruxtecan for people with HER2-negative breast cancer that has spread to the brain. It looks at how well the drug works against brain metastases.
Hear when a new Breast Neoplasms trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.