Neoadjuvant therapy for locally advanced colorectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of chemotherapy, an immunotherapy drug (anti-PD-1 antibody), and sitagliptin before surgery for colorectal cancer that has not spread to other organs. The goal is to see if this approach can shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with colorectal adenocarcinoma (a type of colorectal cancer).
- You are between 18 and 75 years old.
- Your cancer is considered locally advanced (stage T3-4a or N1-2) and has not spread to distant organs.
- Your tumor is pMMR (proficient mismatch repair), meaning it has a normal repair system for DNA.
- You are able to undergo chemotherapy and have no major organ diseases like severe heart, lung, or kidney problems.
- You do not have diabetes or impaired glucose tolerance that would require medication.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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