Clin2
NCT07393919Possibly a fitNot yet recruiting

Stopping antidepressants in treated depression

Depression - Major Depressive Disorder

Part of Mental health clinical trials.

This trial tests different ways to safely stop taking antidepressants for people whose depression is in remission. It aims to find the best strategy to reduce withdrawal and prevent relapse.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
150 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 or older
  • You have been diagnosed with depression (single or recurrent episodes)
  • You have been taking the same antidepressant for at least 6 months
  • Your antidepressant dose has been stable for the past 2 months
  • You currently have no or very low depression and anxiety symptoms
  • Your doctor agrees it is appropriate to try stopping your antidepressant

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07680140Not yet recruiting· Phase 4
Using biomarkers to choose depression treatment

This study uses a blood test (biomarker) to help pick the antidepressant that might work best for you. It compares two treatments—standard antidepressants and ketamine—in people with major depression who haven't gotten enough relief from one prior treatment.

New York, New York
NCT06793397Recruiting· Phase 3
Study of an experimental psychedelic-like drug for depression (CYB003)

This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.

Birmingham, Alabama
NCT07398053Not yet recruiting
Tapering long-term antidepressants with support from your GP and pharmacist

This trial tests whether support from your family doctor and pharmacist helps you safely stop taking an antidepressant you've been on for a long time—if you are no longer depressed. It is for people who are stable and want to try tapering off.

NCT06054321Recruiting
Depression medication study for adults 19 to 65

This study tests a new way of choosing antidepressants for people with major depression. It's designed for adults aged 19–65 who have moderate to severe depression and are either starting a new antidepressant or have been off psychiatric meds for at least a month.

Gwangju
NCT06796946Not yet recruiting· Early Phase 1
Reducing antidepressant use in primary care

This study looks at whether people can safely lower or stop their antidepressant medication with support from their primary care doctor. It's for adults who have been taking an antidepressant for at least a year and can visit their health center.

Cadiz
NCT05002309Recruiting· Phase 2
Pausing depression treatment early to see if it helps

This Phase 2 study tests whether stopping treatment early affects depression outcomes in teens and young adults. It is mainly for people recently diagnosed with depression who need treatment but can participate in psychological therapy.

Halifax, Nova Scotia

Hear when a new Depression - Major Depressive Disorder trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.