Radiation and immunotherapy before surgery for sarcoma
Part of Cancer, Injuries & trauma clinical trials.
This trial tests if giving a short course of radiation therapy combined with immunotherapy before surgery can improve outcomes for people with soft tissue sarcoma in the belly or pelvis. It is for patients whose tumors are hard to remove completely without this pre-treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a soft tissue sarcoma in your belly or pelvis (not other types like GIST or desmoid).
- The tumor should be removable with surgery, and doctors think you need radiation before surgery.
- You must be at least 18 years old and in good enough health to have surgery and radiation.
- Your kidneys, liver, and blood counts must work well enough (your doctor will test this).
- You cannot have cancer that spread to other organs or have had radiation to the same area before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests giving a shorter, lower-dose radiation treatment before surgery for a retroperitoneal (deep belly/back space) soft-tissue sarcoma. The goal is to shrink or control the tumor and make surgery more effective and safe.
This trial tests whether adding immunotherapy drugs (anlotinib and penpulimab) to radiation before surgery can help treat soft tissue sarcoma—a type of cancer in muscles, fat, or connective tissue. The goal is to shrink the tumor and improve surgical outcomes.
This trial tests a new combination of radiation therapy and an immunotherapy approach (called PraG) for people with advanced soft tissue sarcoma that can't be removed by surgery or has spread. The goal is to see if this treatment can shrink tumors and improve outcomes.
This study tests whether a short course of radiation before surgery can treat retroperitoneal sarcoma (a rare cancer in the back of the belly). It is for people whose tumor is removable and who have not had previous radiation in the same area.
This trial tests a newer way of giving radiation (spatially fractionated) compared to standard radiation for people with large soft tissue sarcomas. It aims to see if the new method works better.
This Phase 2 trial tests whether giving radiation before surgery, along with anlotinib and penpulimab, can improve treatment for localized soft tissue sarcoma. It may help shrink or control the tumor before conservative surgery.
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