Stem cell injection to prevent severe mouth sores in transplant
Treatments studied
Part of Digestive system, Mouth & dental clinical trials.
This trial is testing a single injection called Amimestrocel to prevent severe mouth sores in people getting a stem cell transplant. The study is for adults who are receiving high-dose conditioning with total body irradiation or melphalan, which often cause painful mouth inflammation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You are about to have a stem cell transplant from a donor, using high-dose chemo or radiation to prepare your body.
- Your pre-transplant plan includes total body irradiation or the drug melphalan.
- You feel well enough to do everyday activities (ECOG 0 or 1).
- Your heart, liver, and kidneys are working well enough.
- You have no allergy to stem cells or the study injection, and no recent history of cancer or serious infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests a type of light treatment (photobiomodulation) placed in the mouth to help prevent painful mouth sores (oral mucositis) in adults getting a stem cell transplant. It may help reduce mouth discomfort and complications during transplant recovery.
This trial tests if a low-power laser can prevent painful mouth sores and throat pain in people getting a stem cell transplant from a donor. The laser is applied to the mouth before sores start, aiming to reduce pain and speed healing.
This study tests whether a special, standardized mouth care routine can reduce mouth sores (called oral mucositis) in children getting a stem cell transplant. The care routine is simple and may help prevent painful mouth sores, making the transplant experience easier.
This study tests whether a coconut oil mouth rinse can help prevent mouth sores in children and young adults who are about to receive intense chemotherapy for a stem cell transplant. If mouth sores can be prevented, it may make treatment more comfortable and reduce complications.
This trial tests if a medication called etamsylate can help prevent bleeding in patients getting a stem cell transplant. If your platelet count drops very low after transplant, this drug may reduce your risk of bleeding.
This study tests whether a special mouthwash made from copaiba (a natural oil) plus low-level laser therapy can prevent mouth sores caused by high-dose chemotherapy before a stem cell transplant. It might help reduce pain and trouble eating during your transplant treatment.
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