Clin2
NCT07405606Possibly a fitNot yet recruiting

Psilocybin therapy for depression and alcohol problems

Major Depressive Disorder (MDD)Alcohol Use Disorder (AUD)

Treatments studied

Part of Mental health clinical trials.

This study tests whether psilocybin (a psychedelic compound) combined with talk therapy can help people who have both major depression and alcohol use disorder. The goal is to see if it can improve mood and reduce drinking.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You must be between 18 and 65 years old.
  • You must have a current diagnosis of moderate to severe depression and also have alcohol use disorder.
  • You need to be willing to stop certain medications like antidepressants or anti-craving drugs for at least 2 weeks before the study starts.
  • You should not have used hallucinogens (like LSD or magic mushrooms) in the past 5 years, and your lifetime use should be fewer than 10 times.
  • You must not have certain heart, liver, or psychiatric conditions that could make the study unsafe.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06072898Recruiting· Phase 2
Psilocybin brain imaging trial for depression

This study tests whether a single dose of psilocybin (a psychedelic compound) can help treat depression by looking at brain changes on MRI. It is designed for people with moderate-to-severe depression who have not responded well to other treatments.

Toronto, Ontario
NCT07638553Recruiting· Phase 3
Psilocybin to prevent alcohol relapse with depression

This study tests whether psilocybin (a psychedelic compound) can help people with severe alcohol use disorder stay sober longer, especially if they also have depression. Participants receive guided psilocybin sessions alongside counseling to reduce the risk of returning to heavy drinking.

Bayonne
NCT06349083Recruiting· Phase 2
Psilocybin-assisted treatment for alcohol use disorder

This study tests whether psilocybin, a psychedelic drug, combined with therapy can help people reduce or stop drinking. It aims to understand how psilocybin affects the brain and behavior in people with alcohol use disorder.

New York, New York
NCT07296094Not yet recruiting· Phase 2
Psilocybin and therapy for severe alcohol use disorder

This study tests whether a therapy that uses a psychedelic substance called psilocybin (a hallucinogen) can help people with severe alcohol problems. You would receive it in a supervised setting along with talk therapy, with the goal of helping you cut back or stop drinking.

Boston, Massachusetts
NCT05995769Recruiting· Phase 2
Psilocybin therapy with talk therapy for alcohol problems

This trial tests whether psilocybin (the active ingredient in magic mushrooms), given with talk therapy, can help people who want to reduce their heavy drinking. It is for people with at least moderate alcohol use disorder who are motivated to change.

Calgary, Alberta
NCT07281352Recruiting· Phase 1/Phase 2
Psilocybin therapy for depression

This study tests if psilocybin (a psychedelic) combined with cognitive behavioral therapy (CBT) can help people with major depression. You would receive the psilocybin in a supervised setting and have talk therapy before and after.

Los Angeles, California

Hear when a new Major Depressive Disorder (MDD) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.