Study of sapablursen for phlebotomy-dependent polycythemia vera
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests an investigational drug called sapablursen for people with polycythemia vera who still need frequent phlebotomies. The goal is to see if the drug can reduce the need for blood removal and help control the disease safely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have polycythemia vera diagnosed using the latest 2022 criteria.
- You need regular blood removal (phlebotomy) to keep your red blood cells in check.
- Your hematocrit level is below 45% when the study starts.
- If you take medication to lower blood counts, your dose has been stable.
- You have not had a blood clot (like a stroke or heart attack) in the past month.
- You have never taken sapablursen or similar drugs (TMPRSS6 inhibitors) before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study tests a new medicine called rusfertide for polycythemia vera (PV)—a blood condition where your body makes too many red blood cells. The trial aims to see if rusfertide can help reduce the need for blood removal procedures (phlebotomy) that PV patients currently need to manage their condition.
This Phase 2 trial tests a combination of pegylated interferon and ruxolitinib in adults with polycythemia vera who can’t tolerate hydroxyurea or don’t respond well to it. If you qualify, it may help control blood counts and disease symptoms when standard treatment hasn’t worked.
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