Study of a new drug plus standard chemo for advanced colorectal cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests if adding the experimental drug pelareorep to standard chemotherapy (FOLFIRI) and bevacizumab can help people with a specific type of advanced colorectal cancer that has a RAS mutation and is not caused by high microsatellite instability. You may be able to join if you've already tried one type of chemotherapy and it stopped working or you couldn't tolerate it.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your cancer is advanced and cannot be removed with surgery.
- You have a RAS mutation and your tumor is not MSI-high (a type of genetic instability).
- You have already tried a first-line chemotherapy that included oxaliplatin, and it either didn't work or you couldn't continue it.
- You are healthy enough to get standard chemotherapy (FOLFIRI with bevacizumab).
- You have not had irinotecan (a drug in FOLFIRI) before.
- You do not have active autoimmune disease or serious infections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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