Fludrocortisone for septic shock
Treatments studied
Part of Infections clinical trials.
This study tests whether adding a steroid called fludrocortisone to standard care helps people with septic shock (a dangerous drop in blood pressure from infection) get better faster. If you are in the ICU, on a breathing machine, and need strong medication for your blood pressure, you may be eligible.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- You have sepsis (a severe infection affecting your whole body) and your blood pressure is very low despite treatment.
- The low blood pressure started within the last 24 hours.
- You are on a strong drip medication to keep your blood pressure up (like norepinephrine) for at least one hour.
- You are on a breathing machine (ventilator).
- You are not pregnant, and you do not have any condition that would prevent you from taking the study drug (like a severe allergy or a terminal illness).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether two medicines (hydrocortisone and fludrocortisone) can help people with severe infections that cause dangerously low blood pressure (septic shock). It's for patients who have just been diagnosed and haven't used steroids recently.
This trial studies a quick set of tests to figure out whether a person with severe infection (sepsis) will respond to corticosteroids like hydrocortisone. The goal is to guide treatment sooner and avoid ineffective care.
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This study tests whether a corticosteroid (a type of anti-inflammatory medicine) can help people with severe breathing problems or serious infections who have a specific 'hyperinflammatory' pattern. If you are in the ICU on a ventilator, this trial may be an option for you.
This study tests if giving fewer fluids (other than the fluids to keep blood pressure up) can help people recover from septic shock. It compares a reduced fluid strategy to the usual care in the ICU.
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