Clinical trials
Sepsis clinical trials
Below are recruiting sepsis clinical trials, each written for real people, not researchers. We’re tracking 269 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06809868Recruiting
Study of genetic elements in sepsis and aging
This trial looks at how certain genetic elements may affect the immune system in older adults with sepsis. It aims to understand why older patients may respond differently to severe infections.
San Francisco, CaliforniaAges 18 years+ - NCT06657625Enrolling by invitation
Improving sepsis care in the emergency department
This trial looks at a new program to improve how doctors and nurses treat sepsis (a severe infection that can cause organ failure) in the emergency department. It aims to see if the program helps start the right treatments faster.
BrestAges 18 years+ - NCT05975671Recruiting
Survey in pediatric ICU to reduce upfront vancomycin use
This study is a survey and quality-improvement effort in participating children’s intensive care units. It aims to understand and change how doctors decide to start vancomycin (an antibiotic) when sepsis is suspected, to improve care and avoid unnecessary use.
Atlanta, GeorgiaAges Any age - NCT07735182Recruiting
Gut bacteria and organ damage in sepsis
This study looks at how bacteria in your gut and other signs in your body affect liver and kidney damage in people with sepsis. It also compares findings to healthy volunteers to see what is different.
Hangzhou, ZhejiangAges 18 years+ - NCT04130789Recruiting
Personalized study for ICU patients with possible sepsis
This study looks at ICU patients in Swiss university hospitals to understand how to personalize care for people who meet sepsis criteria. It may help doctors better predict who is getting worse and tailor treatment plans.
BaselAges 18 years+ - NCT04203979Recruiting
Sepsis care tailored to patients
This study looks at how to better recognize and manage sepsis (a serious body-wide reaction to infection) and tailor care to the individual. You may be eligible if you are newly admitted to the emergency department and your care is handled by a rapid response team for sepsis.
OsloAges 18 years+ - NCT06018792Recruiting
New blood test for faster sepsis diagnosis in children
This trial tests a new, faster way to find bacteria in the blood of children with suspected sepsis. It uses a molecular test that may give results sooner than standard cultures, helping doctors treat infections more quickly.
AmsterdamAges birth–18 years - NCT06491966Recruiting
Comparing immune responses in bacterial vs. COVID-19 sepsis
This study compares how the body's immune system responds to bacterial sepsis vs. viral sepsis (COVID-19) in intensive care unit patients. The goal is to find better ways to treat each type of life-threatening infection.
Chengdu, SichuanAges 18–90 - NCT06779617Recruiting
Early sepsis detection trial at University of Maryland hospitals
This trial tests a new early warning system (SEPSys and RESCUE scores) to spot sepsis before it gets serious. If you're an adult in a University of Maryland hospital without sepsis, the system may help your doctors act faster.
Baltimore, MarylandAges 18 years+ - NCT07079605Recruiting
Sepsis and heart inflammation study
This trial looks at how sepsis (a severe response to infection) affects the heart, specifically whether it causes inflammation of the heart muscle (myocarditis). It may help understand and improve care for people with sepsis.
Jimma, OromiyaAges 18 years+ - NCT07451886RecruitingPhase 2
Fludrocortisone for septic shock
This study tests whether adding a steroid called fludrocortisone to standard care helps people with septic shock (a dangerous drop in blood pressure from infection) get better faster. If you are in the ICU, on a breathing machine, and need strong medication for your blood pressure, you may be eligible.
Hong KongAges 18 years+ - NCT07397689Recruiting
Early Sepsis Detection Tool for Children
This trial checks if a new tool can help doctors spot sepsis early in children. If your child is under 18, had a blood culture, and received strong antibiotics within the first day in the hospital, they may qualify.
ShanghaiAges Up to 18 years - NCT03244293Recruiting
Using a brain monitoring number to grade sepsis severity
This trial tests whether a bedside monitoring number called BIS can help sort sepsis into severity levels. If you have sepsis in the ICU, it may help clinicians track how serious it is and guide care.
Dalian, DalianAges Any age - NCT04103268Recruiting
Study blood tests to understand organ injury in children with sepsis
This study uses special blood testing to learn what is happening in the immune system during sepsis in children and how it may relate to organ injury. Your results may help doctors recognize and treat sepsis earlier and more accurately.
Boston, MassachusettsAges 1 month–17 years - NCT04103281Recruiting
Blood test study of immune cell markers in ICU sepsis
This trial looks at patterns in certain immune cells (neutrophils) in people with sepsis in the ICU, including those who have a breathing tube. It may help doctors better understand how the immune system changes during sepsis and could guide future care.
Boston, MassachusettsAges 2–50 - NCT05491941Recruiting
Testing ways to improve care for sepsis patients
This trial looks at how to best put proven sepsis care steps into practice in the emergency department. It may help you or other patients receive faster, more consistent treatment for sepsis.
Providence, Rhode IslandAges 18 years+ - NCT05634733Recruiting
Testing how a heart ultrasound finding changes in sepsis treatment
This study looks at how a measurement from a bedside heart ultrasound changes while treating people with sepsis or septic shock. It may help doctors understand how to monitor response to treatment using a quick ultrasound test.
Baltimore, MarylandAges 18 years+ - NCT05758246RecruitingPhase 2
Fisetin to slow worsening of sepsis in older hospital patients
This Phase 2 trial tests whether a drug called fisetin can slow the progression of sepsis once you are admitted to the hospital. It may help patients recover more quickly or avoid worsening, but eligibility depends on how severe the illness is and what other treatments you need.
Gainesville, FloridaAges 65 years+ - NCT06103500Recruiting
Helping choose the right antibiotic for sepsis
This trial tests a computer tool to help doctors choose the right antibiotic for sepsis early on. It may help improve treatment by providing personalized recommendations based on your condition.
Mississauga, OntarioAges 18 years+ - NCT06145724Recruiting
Reducing maternal sepsis complications in New York City hospitals
This study looks at hospital records to find ways to reduce serious infections (sepsis) in mothers after childbirth. It aims to improve care and save lives.
New York, New YorkAges Any age - NCT06178822Recruiting
New blood tests to diagnose sepsis in the ER
This study aims to find new ways to quickly diagnose sepsis (a severe response to infection) in patients arriving at the emergency room. If successful, these new tests could help doctors start treatment faster.
Almere Stad, FlevolandAges 18 years+ - NCT06323226Recruiting
Sepsis long-term outcomes in critically ill children
This study looks at how sepsis (a severe infection that can affect the whole body) affects children after they leave the intensive care unit. It compares children who had sepsis to those with other critical illnesses to understand long-term health.
Chengdu, SichuanAges birth–16 years - NCT06446947Recruiting
Blood markers for poor outcomes after sepsis in cancer surgery
This study looks at blood markers (epigenetics) to better understand why some people have a harder time recovering from a severe infection after major cancer surgery. The goal is to find early signs of poor outcomes in men aged 45–75 with post-surgery sepsis.
Marseille, Bouches du RhôneAges 45–75 - NCT06766461RecruitingPhase 4
Optimizing antibiotic dosing in ICU patients with septic shock
This trial checks if giving higher doses of beta-lactam antibiotics (a type of strong antibiotic) right from the start helps people in the ICU with septic shock. It aims to find the best dose to fight the infection quickly.
RotterdamAges 18 years+
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Sepsis trials by city
Studies with a site in or near these metro areas.
Sepsis trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for sepsis?
- Yes. Clin2 currently lists 269 recruiting sepsis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sepsis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sepsis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.