Chemo, radiation, and immunotherapy for high-risk rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a treatment plan that combines chemotherapy, radiation, and an immunotherapy drug before surgery for people with high-risk locally advanced rectal cancer. The goal is to see if this approach can improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You have a type of rectal cancer called adenocarcinoma that is mismatch repair proficient (pMMR) or microsatellite stable (MSS).
- Your cancer is in the middle or lower part of the rectum (within 10 cm of the anus) and considered high-risk, meaning it has certain features like being stage T4 or involving nearby structures.
- You have not had any previous treatment for this rectal cancer, such as surgery, chemotherapy, or radiation.
- You are in generally good health (ECOG performance status 0 or 1) and have adequate organ function, as determined by blood tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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