Short-course radiation with chemo and immunotherapy for high-risk rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of short-course radiation, chemotherapy (CAPOX), and an immunotherapy drug (PD-1 inhibitor) for people with high-risk locally advanced rectal cancer. The goal is to see if this approach can improve outcomes before surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with rectal adenocarcinoma that is locally advanced and considered high-risk (e.g., tumor stage cT4, lymph node stage cN2, or other high-risk features).
- Your tumor is within 10 cm of the anal opening.
- You have not had any prior treatment for rectal cancer (like chemotherapy, radiation, or surgery).
- You are in good general health (able to perform daily activities with little to no help, and lab tests show adequate blood counts and organ function).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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