High dose rhTPO vs switching to eltrombopag for ITP
Part of Blood & lymphatic, Immune system & allergy clinical trials.
This trial tests two ways to raise platelets for people with immune thrombocytopenia (ITP) who did not respond well to a short course of the platelet-boosting drug rhTPO. One group gets a higher dose of rhTPO, the other switches to a different oral medication, eltrombopag. The goal is to see which approach works better to increase platelet counts safely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 12 and 75 years old.
- You have been diagnosed with ITP based on a bone marrow biopsy or other tests done within the last 3 months.
- You tried rhTPO for 14 days or less and your platelets stayed below 30.
- Your other blood counts (like ANC and hemoglobin) and organ functions (liver, kidneys, clotting) are mostly normal or any issues are clearly from ITP.
- You have not used certain other ITP treatments for at least 2 weeks, or you are on a stable dose of certain maintenance medications for at least a month.
- If you are a woman who could become pregnant, you must have a negative pregnancy test and agree to use effective birth control during and for 6 months after the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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