Psilocybin under brain-wave-guided anesthesia for depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether giving a psychedelic drug called psilocybin during carefully monitored anesthesia can help treat major depression. You'll receive the drug or a placebo during a short procedure while your brain waves are tracked, and researchers will follow your mood over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 25 and 65 years old.
- You must have a current diagnosis of major depressive disorder (a major depressive episode lasting at least 4 weeks).
- You need to be stable on your current psychotherapy (talk therapy) for at least 4 weeks before starting.
- You must be in good physical health overall, with a body mass index (BMI) between 17 and 35.
- You must agree to avoid alcohol, cannabis, and certain medications and supplements during the study, and to fast after midnight before dosing sessions.
- You cannot be pregnant or breastfeeding, and you must use effective birth control if you could become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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