Adding venlafaxine to standard rheumatoid arthritis treatment
Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.
This study tests whether adding venlafaxine (an antidepressant) to your usual arthritis treatment can help reduce inflammation and improve symptoms like pain and fatigue. It may be an option if your arthritis is still active despite current medications and you are not already on antidepressants or biologics.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older and have a confirmed diagnosis of rheumatoid arthritis.
- You need to have been on your current arthritis medicines (like methotrexate or sulfasalazine, with or without steroids) for at least 6 months.
- Your arthritis must still be active — meaning you have moderate to high disease activity despite your current treatment.
- You cannot be taking biologics or other targeted treatments for RA.
- You must not be pregnant or breastfeeding, and you must not have uncontrolled high blood pressure, unstable heart problems, significant kidney or liver disease, or a high risk of bleeding.
- You cannot be taking other antidepressants or have unstable psychiatric conditions (like psychosis, mania, suicidal thoughts, or substance abuse).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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