Testing OPK-88006 for Fatty Liver Disease
Part of Digestive system clinical trials.
This trial tests a new experimental drug called OPK-88006 to see if it can help treat MASH, a serious liver condition linked to excess fat buildup. The study has two parts: one with healthy volunteers to check safety, and one with people who have signs of fatty liver disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18–65 years old (Part A) or 18–75 years old (Part B)
- Have a BMI between 27–35 (Part A) or 27–40 (Part B), meaning you are overweight or obese
- For Part B only: have signs of MASH (fatty liver disease with metabolic problems like high blood sugar or cholesterol)
- Not have serious uncontrolled medical or mental health conditions
- Not have a history of pancreatitis, cancer in the past 5 years, or substance misuse
- Not currently taking weight-loss medications like GLP-1 agonists (semaglutide, tirzepatide) or other obesity drugs
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether efimosfermin, an experimental drug, can safely help people with MASH (a fatty liver disease) that has led to cirrhosis (liver scarring) but the liver is still working well (compensated). Participants will be randomly assigned to receive the drug or a placebo.
This study is testing a new drug that targets thyroid hormone receptors in the liver, alone or combined with another drug, to reduce inflammation and scarring in people with MASH (a type of fatty liver disease). If you have MASH with moderate liver scarring and are otherwise healthy, this trial may help find a new treatment option.
This trial tests a new medicine, HSK31679, for people with MASH (a type of fatty liver disease with inflammation and scarring). It aims to see if the drug can help improve liver health.
This trial tests a new drug, IMM-H014, for a liver condition called MASH (metabolic dysfunction-associated steatohepatitis). It looks at how well people tolerate the drug and how it works in the body. This might help if you have fat buildup in your liver along with other health issues like high blood pressure, diabetes, or high cholesterol.
This study tests a new drug called ALN-CIDEB for people with fatty liver disease (MASLD or MASH). The goal is to see if it can reduce liver fat and improve liver health. You may qualify if you have a higher BMI and evidence of liver fat on imaging tests.
This study tests an investigational medicine (BI 3802876) in people with early-stage liver cirrhosis due to MASH. The goal is to see if it is well tolerated and potentially helpful.
Hear when a new MASH trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.