Clin2
NCT07512921Possibly a fitRecruiting

Gene Expression Study for HPV-Negative Head and Neck Cancer

Head and Neck (HNSCC)

Part of Cancer clinical trials.

This study compares gene patterns in tumor tissue and blood samples from patients with HPV-negative head and neck cancer. Understanding these patterns may help doctors better understand the disease and develop better treatments.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
300 people
Ages
18 years and older
Study type
Observational

Who can take part

  • You have been diagnosed with squamous cell carcinoma (a type of cancer) in your head and neck
  • Your cancer is in one of these locations: mouth, throat, voice box, or lower throat
  • Your cancer is stage III or IV (advanced but not spread to distant organs)
  • Your cancer does not have HPV (human papillomavirus) or p16 protein markers
  • You are being treated with the goal of curing the cancer
  • You can follow the study procedures and visits

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06706973Recruiting
Epigenetic study for new head and neck cancer treatments

This trial studies the role of epigenetic marks in head and neck cancer to improve diagnosis and treatment. If you have been newly diagnosed with head and neck squamous cell carcinoma and have not yet received treatment, you may be eligible to participate.

Milan, MI
NCT04681469Recruiting· Phase 2
Niraparib plus immunotherapy for HPV-negative head and neck cancer

This Phase 2 study tests a cancer “induction then maintenance” plan using a PARP inhibitor (niraparib) along with immunotherapy (TSR-042) in people with HPV-negative head and neck squamous cell cancer. If it works, it may improve control of the cancer after surgery by boosting the immune system and targeting cancer cells’ DNA repair.

Brescia
NCT06642324Recruiting
HPV and genetics in head and neck cancer study

This study looks at how HPV infection and genetic changes relate to head and neck squamous cell carcinoma. If you have this type of cancer, joining could help doctors learn more about the disease and improve future treatments.

Dhaka, Dhaka Division
NCT06744296Recruiting
ctDNA surveillance for HPV-negative head and neck cancer

This trial uses a blood test to look for tiny bits of tumor DNA after treatment for head and neck cancer. It aims to see if this test can detect any remaining cancer cells early, so you and your doctor can make informed decisions.

Boston, Massachusetts
NCT04564989Recruiting
Biomarker study for HPV-related throat cancer outcomes

This observational study checks how well a blood test for HPV DNA (and other tumor genetic markers) predicts outcomes in certain throat cancers. It may help doctors better track the disease and plan treatment, because the trial validates these lab signals against real-world results.

Rochester, Minnesota
NCT05539638Recruiting
Testing blood DNA for head and neck squamous cancer

This study looks at how tumor DNA found in a blood sample (a “DNA signal”) relates to head and neck cancer in the oropharynx. It may help doctors understand disease status and improve how they monitor treatment, for both HPV-positive and HPV-negative cancers.

Dundee, DD2 1SG

Hear when a new Head and Neck (HNSCC) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.