EGFR-targeted drug plus immunotherapy for advanced penile cancer
Treatments studied
Part of Cancer, Kidney & urinary clinical trials.
This trial tests a new combination treatment for advanced penile cancer that hasn't been treated before. It combines a targeted drug (becotatug vedotin) designed to attack cancer cells with an immunotherapy drug (pucotenlimab) that helps your immune system fight cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Confirmed penile squamous cell carcinoma (a type of skin cancer of the penis) by biopsy
- Cancer cells must show EGFR expression (a protein marker) on testing
- You have enlarged lymph nodes in the groin or pelvis, OR your cancer is difficult to remove while preserving penis function
- At least one measurable tumor on imaging scans
- Good heart, blood cell, liver, and kidney function based on recent blood tests and heart ultrasound
- No prior chemotherapy, except if you received chemotherapy after surgery more than 6 months ago
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests two drugs, MRG003 and HX008, as a first treatment for men with EGFR-positive penile squamous cell carcinoma that cannot be removed by surgery or has spread. The goal is to see if the combination shrinks tumors or delays growth.
This trial tests two drugs — becotatug vedotin and pucotenlimab — together in people with advanced penile cancer whose tumors show a protein called EGFR. It aims to see if this combination can shrink or slow the cancer.
This trial tests two drugs given before surgery for penile cancer that has spread to nearby tissues or lymph nodes. The goal is to see if this combination can shrink tumors and improve outcomes. The drugs work by helping the immune system attack cancer cells and delivering chemotherapy directly to them.
This trial tests a combination of two chemotherapy drugs (carboplatin and paclitaxel) plus the immunotherapy drug pembrolizumab (Keytruda) for penile cancer that has spread to nearby lymph nodes. The goal is to see if this combination can shrink or control the cancer before or after surgery.
This trial tests a combination of chemotherapy drugs (paclitaxel, ifosfamide, cisplatin) and an immunotherapy drug (triplizumab) given before surgery for locally advanced penile cancer. The goal is to shrink the tumor and improve outcomes.
This trial tests a combination of two drugs, QL1706 and lenvatinib, in people with penile cancer that has already been treated with other therapies. The goal is to see if this new combination can shrink tumors or slow cancer growth.
Hear when a new Penile Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.