Ventilator Pressure Levels During Surfactant Therapy in Preterm Infants
Part of Lungs & breathing clinical trials.
This study tests whether different pressure levels used during a minimally invasive surfactant procedure (MIST)—a way to deliver lung-coating medicine without a breathing tube—affect how well preterm infants' lungs inflate. Researchers hope to find the best pressure settings to help babies breathe more easily.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Baby was born between 24 and 31 weeks and 6 days of pregnancy
- Baby is currently on CPAP (a gentle breathing support that pushes air into the lungs)
- Baby is planned to receive MIST as part of standard care at your hospital
- Baby is less than 72 hours old and can receive MIST within 90 minutes of being assigned to the study
- Baby is clinically stable and able to tolerate a special belt and gel placed on their chest for monitoring
- Parent or guardian can provide informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether giving a pre-medication before a less invasive lung treatment (surfactant) improves breathing in premature babies. It may help some babies avoid more invasive ventilation while still getting the lung medication they need.
This trial tests a less invasive way to give surfactant (a lung treatment) to babies born a few weeks early who need breathing help. It aims to see if this method works as well as standard care.
This trial compares a new method of giving surfactant (a substance that helps babies' lungs work better) to preterm infants who have breathing problems. The goal is to see if giving surfactant through a thin tube without a breathing tube works as well as the usual method.
This trial tests whether giving surfactant (a substance that helps lungs stay open) to premature babies with Respiratory Distress Syndrome (RDS) through a mask on the throat (supraglottic airway) is safe and effective. It may be an option for babies who need extra oxygen but are not on a breathing tube.
This trial compares two ways of giving surfactant (a liquid that helps babies' lungs open) to premature babies who need extra oxygen. One way uses a laryngeal mask airway and the other uses a thin catheter. Both are less invasive than a breathing tube, which may help babies recover faster.
This trial tests whether using a special chest-contouring device (cuirass) that creates gentle negative pressure around the chest can help preterm babies who need surfactant (a substance that helps lungs stay open) breathe better without a breathing tube.
Hear when a new Surfactant Deficiency Syndrome Neonatal trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.