Helping preterm babies breathe with gentle pressure during surfactant therapy
Part of Women’s health & pregnancy clinical trials.
This trial tests whether using a special chest-contouring device (cuirass) that creates gentle negative pressure around the chest can help preterm babies who need surfactant (a substance that helps lungs stay open) breathe better without a breathing tube.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your baby is born at 32 weeks of pregnancy or later
- Your baby needs extra oxygen (more than 30% oxygen for over 30 minutes) while on continuous positive airway pressure (CPAP) or high-flow nasal cannula
- Your baby shows signs of hard work breathing even with low oxygen needs
- Your baby weighs more than 800 grams (about 1 pound 12 ounces) at birth
- A chest X-ray shows respiratory distress syndrome (RDS)
- The hospital has all the needed equipment and a correctly sized chest cuirass for your baby
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a less invasive way to give surfactant (a lung treatment) to babies born a few weeks early who need breathing help. It aims to see if this method works as well as standard care.
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This study tests whether giving a natural lung coating (surfactant) early, using a thin tube rather than a breathing machine, can help very premature babies with breathing problems breathe better and avoid more serious breathing treatments.
This trial tests if giving surfactant (a natural substance that helps lungs stay open) through a special airway device can help late preterm and early term infants with breathing problems. The goal is to see if this approach works better than current methods without needing a breathing tube.
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This trial tests different ways to help very preterm babies when they are first taken off a breathing machine and switched to CPAP. It aims to find the safest and most effective breathing support to help them breathe on their own.
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