Heart valve replacement versus medicines for moderate aortic stenosis
Part of Heart & circulation clinical trials.
This study compares two approaches for people with moderate aortic stenosis: a new type of heart valve replacement device (called Myval) versus standard medical therapy (medicines and monitoring). It aims to see if treating the valve earlier can improve symptoms and heart health compared to waiting until the condition becomes severe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 65 years or older
- You must have moderate aortic stenosis — a moderate narrowing of the main valve that lets blood out of your heart
- You must either have symptoms (like breathlessness, chest pain, or fainting), or if you don't have symptoms, you must have some signs that your heart is being strained (like a weak pumping function, an enlarged heart, or an abnormal heart rhythm)
- Your heart pumping function must not be severely reduced (must be above 20%)
- You must not have had a previous aortic valve replacement or severe leakage of other heart valves
- Your kidney function must be adequate (not on dialysis and with a glomerular filtration rate above 30)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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