Early valve replacement for people with severe but silent aortic narrowing
Part of Heart & circulation clinical trials.
This trial tests whether replacing a badly narrowed aortic valve earlier—even when you feel fine—can prevent future heart problems. It compares early valve replacement (through a catheter or surgery) versus standard watchful waiting.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe aortic valve narrowing based on heart scan measurements (valve area, blood speed, and heart-team review)
- Your symptoms are considered absent (“asymptomatic”) by a cardiology specialist
- You are considered a candidate for valve replacement using either catheter (TAVR) or surgery (AVR)
- Your heart scan or blood test shows early strain or stress signs (such as higher filling pressure, weaker heart squeeze, or abnormal lab results)
- You are 18 to 85 years old and can sign informed consent
- You do NOT have certain exclusions like weak pumping (low LVEF), very severe narrowing, major other valve disease, past valve surgery, kidney failure, dementia, possible pregnancy, or a type of narrowing outside the valve
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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