Sertraline Plus Probiotic for Teen Depression
Part of Mental health clinical trials.
This study tests whether combining sertraline (an antidepressant) with a specific probiotic called Lactobacillus crispatus can safely and effectively treat depression in teenagers. The probiotic may help by improving gut health, which researchers believe could support mental health.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 12 and 18 years old
- Have been diagnosed with major depressive disorder and currently be in a depressed episode
- Score at least 40 on the Child Depression Rating Scale (a measure of depression severity)
- Not have other serious mental health conditions (except anxiety, which is okay)
- Not have tried and failed two or more different antidepressants, or previously not tolerated sertraline
- Not be at high risk for suicide, and not have recently used antibiotics, antifungals, or probiotics
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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