Better treatment for teens with SSRI-resistant depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether switching to a different antidepressant or adding a second medication works better for teens (12-17) whose depression hasn't improved with a first SSRI. It compares two common strategies to find the best next step.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 12 and 17 years old.
- You have been diagnosed with major depression that is not getting better with your current antidepressant.
- You have tried one specific SSRI (like Prozac) for at least 8 weeks at a moderate to high dose, and it didn't work well enough.
- You do not have bipolar disorder, schizophrenia, autism, ADHD, OCD, or psychosis.
- You do not currently have clear plans to harm yourself or a recent suicide attempt.
- You have not already tried two or more different antidepressants that didn't work.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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