Switching or combining medications for teen depression after ssri failure
Treatments studied
Part of Mental health clinical trials.
This trial is for teenagers whose depression has not improved after trying one SSRI antidepressant. It compares switching to a different medication versus adding another medication to see which approach works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 12 and 17 years old.
- You have been diagnosed with major depressive disorder (depression).
- You have tried at least one SSRI antidepressant (like fluoxetine, sertraline) at a standard dose for at least 8 weeks, and it did not work well enough.
- You have not tried two or more different antidepressants at adequate doses.
- You do not have bipolar disorder, schizophrenia, autism, ADHD, OCD, or other serious mental health conditions, and you do not have current suicidal plans.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether combining sertraline (an antidepressant) with a specific probiotic called Lactobacillus crispatus can safely and effectively treat depression in teenagers. The probiotic may help by improving gut health, which researchers believe could support mental health.
This study tests whether combining an antidepressant medication (sertraline) with special bacteria supplements (probiotics) can help treat depression in teenagers ages 12–18. Researchers believe the probiotics may help the medication work better by improving gut health.
This study tests a new medicine called ammoxetine for people with major depression. It aims to see if it can help reduce depressive symptoms.
This study tests a new combination of two medications (dextromethorphan and bupropion) as a treatment for major depressive disorder. It may be an option if you have not already tried many antidepressants that didn't work.
This trial tests a step-by-step approach to treating moderate-to-severe depression in teens. It may help find a treatment path that improves mood while keeping care safe, including for some teens who have suicidal thoughts but do not need inpatient care.
This study tests a new way of choosing antidepressants for people with major depression. It's designed for adults aged 19–65 who have moderate to severe depression and are either starting a new antidepressant or have been off psychiatric meds for at least a month.
Hear when a new Major Depressive Disorder (MDD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.