Testing Samelisant for Narcolepsy Daytime Sleepiness
Part of Brain & nervous system, Mental health clinical trials.
This study tests whether a new medication called samelisant can reduce extreme daytime sleepiness and sudden muscle weakness (cataplexy) in people with narcolepsy. If it works, it could offer a new treatment option for managing this sleep disorder.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of narcolepsy (with or without sudden muscle weakness episodes)
- Your body mass index is between 18 and 45 kg/m²
- You experience significant daytime sleepiness or at least 4 muscle weakness episodes per week (if you have the type with cataplexy)
- You're willing to stop certain narcolepsy medications for at least 2 weeks before the study starts
- You keep a consistent sleep schedule (going to bed before 1 am, waking before 9 am, sleeping at least 6 hours per night)
- You can commit to keeping detailed sleep records and following all study procedures
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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