Clin2
NCT07557316Possibly a fitNot yet recruiting

Tumor response after pre-surgery treatment for rectal cancer

Rectal Cancer PatientsTotal Neoadjuvant Therapy

Part of Cancer clinical trials.

This study looks at how well the tumor responds to pre-surgery treatment in people with locally advanced rectal cancer. It compares two ways of measuring response to see which better predicts long-term survival, which may help guide future treatment decisions.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
100 people
Ages
18 years and older
Study type
Observational

Who can take part

  • You were 18 or older when diagnosed with rectal adenocarcinoma (a type of rectal/colon cancer).
  • Your cancer was stage II or III at diagnosis (locally advanced, not spread to distant organs).
  • Before surgery, you received total neoadjuvant therapy (TNT): chemoradiation plus chemo, or short-course radiation plus chemo.
  • You had surgery (TME) to remove the cancer after your pre-surgery treatment.
  • You had no distant metastasis at diagnosis and had complete medical records available.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06758830Recruiting· Phase 2/Phase 3
Total neoadjuvant therapy vs surgery for rectal cancer

This trial tests whether a full course of chemotherapy and radiation before any surgery (called total neoadjuvant therapy) can help you avoid surgery and preserve your rectum. It is for people with a specific early stage of rectal cancer that has not spread.

Vilnius
NCT04842006Recruiting
Personalized treatment plan for rectal cancer before and after surgery

This trial looks at a personalized treatment approach for rectal cancer. It aims to guide the best chemotherapy and (if needed) radiotherapy before and after surgery, based on scans and specific test results.

Helsinki, Uusimaa
NCT07346248Enrolling by invitation
Complications after pre-surgery treatment for advanced rectal cancer

This study looks at complications that happen after surgery in patients with advanced rectal cancer who got radiation or chemo-radiation before their operation. Researchers want to learn how different pre-surgery treatments affect recovery.

Rozzano, Milan
NCT05883800Recruiting
Total treatment with tailored radiation for advanced rectal cancer

This study tests a “total neoadjuvant” approach—chemotherapy first, then radiation—using adaptive (tailored) radiation planning for people with locally advanced rectal cancer. It may help improve tumor control while adjusting the radiation based on how your cancer and anatomy respond.

Bergen
NCT05939661Recruiting· Phase 2
Total treatment before surgery for early rectal cancer

This Phase 2 study tests a “total neoadjuvant” approach, meaning you receive cancer treatment before surgery, to improve safety and effectiveness for rectal cancer. It may help by shrinking the tumor and planning a more effective operation, while researchers carefully track side effects.

Osaka
NCT06637462Recruiting
Studying standard treatment response before rectal cancer surgery

This study looks at how rectal cancer responds to the usual chemotherapy and radiation given before surgery. It aims to learn if certain molecular features of your tumor can predict how well it responds to treatment.

Middletown, New Jersey

Hear when a new Rectal Cancer Patients trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.