Immunotherapy plus chemotherapy for early rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests whether adding an immunotherapy drug called tislelizumab to standard chemotherapy and radiation can help patients with early-stage rectal cancer (cancer within 3 cm of the opening of the rectum) avoid surgery or improve surgery outcomes. The goal is to see if this combination is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–75 years old
- Diagnosed with rectal adenocarcinoma (a specific type of rectal cancer) confirmed by biopsy
- Cancer is located within 3 cm of the dentate line (a specific landmark inside the rectum)
- Cancer has not spread to distant organs, and lymph node involvement is limited (stage cT1-3 N0-1M0)
- No prior cancer treatment for rectal cancer
- Good overall health and able to tolerate chemotherapy, radiation, and potential surgery
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if adding immunotherapy to standard chemotherapy and radiation before surgery helps shrink high-risk rectal cancer and prevent it from coming back. You may be a good fit if you have a specific type of advanced rectal cancer that hasn't spread to other parts of your body.
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