ALS Study: Testing a New Drug in Spinal Fluid
Treatments studied
Part of Brain & nervous system, Hormones & metabolism clinical trials.
This is a follow-up study for people with ALS (a disease affecting nerve and muscle control) who completed a previous trial called OWAA. Researchers want to test how a new experimental drug called LY4256984 affects the spinal fluid around your brain and spine, which may help them understand if it could slow disease progression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have finished the entire main treatment phase and any off-treatment period of the parent OWAA study
- You cannot have a history of significant back pain, back disease, spinal surgery, or spine deformity that could complicate a spinal tap
- You cannot be allergic to local anesthetics like lidocaine (numbing medicine used during spinal tap)
- You must not have a current infection where the spinal tap needle would go
- Your blood platelet count must be at least 100,000 per cubic millimeter, and you cannot have bleeding disorders or take blood-thinning medications (except low-dose aspirin is allowed)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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