Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 190 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07224269RecruitingEarly Phase 1
Terazosin for energy levels in ALS
This study tests whether a blood pressure medicine called terazosin can boost energy production in cells of people with ALS, potentially slowing the disease. It involves taking the medication daily for a period and monitoring safety and effects.
Iowa City, IowaAges 18–80 - NCT06656702RecruitingEarly Phase 1
Psilocybin for depression in amyotrophic lateral sclerosis
This trial tests whether psilocybin, a psychedelic drug, can safely help with depression in people with ALS. It also looks at how the drug affects your symptoms and quality of life over six months.
Baltimore, MarylandAges 18 years+ - NCT07571486RecruitingPhase 1/Phase 2
Opening the blood-brain barrier for ALS treatment
This trial tests a device that temporarily opens the barrier between the blood and brain to see if it can help slow down ALS. It may allow treatments to reach the brain more effectively.
ParisAges 18–80 - NCT06147843Recruiting
Study on weight loss in ALS patients from France and Germany
This study looks at why some people with ALS lose weight and what factors are involved. It follows patients in France and Germany to better understand weight changes and help improve care.
LilleAges 18 years+ - NCT04394871Recruiting
Study of ALS and related genetic nerve disorders using scans and fluid tests
This study looks at signs and biology (biomarkers) in people with certain inherited nerve conditions caused by RNA-processing gene changes. It may help researchers understand disease patterns and measure health changes using MRI scans and sometimes a spinal fluid test.
Bethesda, MarylandAges 5–120 - NCT07413718Recruiting
Breathing muscle training for ALS patients
This study tests whether a special breathing muscle training can help people with ALS maintain lung function. It may benefit patients diagnosed recently with spinal ALS and good breathing capacity.
Donostia / San Sebastian, GipuzkaAges 18–85 - NCT07257302Recruiting
Breathing muscle training for ALS patients
This study tests whether a special breathing exercise called Lung Insufflation Capacity (LIC) training can help people with ALS maintain or improve their breathing muscle strength. Participants must be age 20 or older, have a confirmed ALS diagnosis, and not be using a breathing machine at the start of the training.
Kodaira, TokyoAges 20 years+ - NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
Birmingham, AlabamaAges 18 years+ - NCT07023835RecruitingPhase 2
Testing usnoflast for ALS
This trial tests an experimental oral medication called usnoflast for people with ALS. It aims to see if the drug can slow the disease's progression.
La Jolla, CaliforniaAges 18 years+ - NCT07726563Recruiting
Plasmapheresis for ALS with NRIP2 antibody
This trial tests whether a blood filtering treatment called plasmapheresis can help people with ALS who have a specific antibody (NRIP2) in their blood. It aims to see if removing this antibody can slow the disease and improve symptoms.
Taipei City, TaipeiAges 20 years+ - NCT06351592RecruitingPhase 1/Phase 2
Study of ALN-SOD for ALS with SOD1 gene mutation
This trial tests an experimental drug called ALN-SOD for people with ALS caused by a specific genetic mutation in the SOD1 gene. The goal is to see if it is safe and can help slow the disease.
Concord, New South WalesAges 18 years+ - NCT06719947RecruitingPhase 2/Phase 3
Brain stimulation for ALS: a controlled trial
This study tests whether a non-invasive brain stimulation technique called HD-tDCS can help people with ALS. It is a randomized trial, meaning participants are assigned by chance to receive the real stimulation or a placebo, to see if it slows disease progression.
Brasília, Federal DistrictAges 18–80 - NCT07571200RecruitingPhase 1
Study of LY4256984 for ALS in Previous Trial Participants
This is a follow-up study for people with ALS who have already completed another Eli Lilly ALS treatment trial. Researchers want to continue testing a new drug (LY4256984) in people who tolerated the previous treatment well.
LeuvenAges 18–80 - NCT07571174RecruitingPhase 1
ALS Study: Testing a New Drug in Spinal Fluid
This is a follow-up study for people with ALS (a disease affecting nerve and muscle control) who completed a previous trial called OWAA. Researchers want to test how a new experimental drug called LY4256984 affects the spinal fluid around your brain and spine, which may help them understand if it could slow disease progression.
LeuvenAges 18–80 - NCT03225144Recruiting
Study of gene and disease changes in ALS and frontotemporal dementia
This study looks at complex brain and body changes in people with ALS and frontotemporal dementia (FTD), or related disorders. If you have one of these diagnoses—or a known gene mutation that can cause ALS/FTD—you may be able to help researchers learn how the conditions progress.
Bethesda, MarylandAges 18–110 - NCT03489278Recruiting
Support procedures study for ALS using electronic health records
This study is about improving the research process for people with ALS by using electronic health records from participating clinics. If you have ALS and receive care at an Epic-using center, you may be asked to help with consent and study procedures.
Irvine, CaliforniaAges 18 years+ - NCT04008329Recruiting
Study of people with amyotrophic lateral sclerosis
This study follows people living with amyotrophic lateral sclerosis (ALS) over time. It may help researchers better understand ALS and track changes that could guide future treatments.
Fuzhou, FujianAges Any age - NCT04097158Recruiting
Study of blood markers in ALS people taking edaravone
This trial studies blood or other lab markers in people with ALS, including different ALS patterns, to better understand how the disease works and responds to treatment with edaravone. You may be helped by close monitoring, and the results may guide future ALS care.
Loma Linda, CaliforniaAges 18–85 - NCT04454892Recruiting
Study of ALS symptoms and disease course
This study watches people with ALS over time to better understand how symptoms change and what features show up. It may help future care and treatments by improving doctors’ understanding of ALS’s natural course.
BeijingAges Any age - NCT04721717Recruiting
Workshop for healing writing after paralysis
This trial tests whether a structured writing workshop can help people living with paralysis and their ALS caregivers. It focuses on communication through words (spoken or written) to support well-being.
Birmingham, AlabamaAges 18 years+ - NCT04868994Recruiting
MRI study to help diagnose amyotrophic lateral sclerosis (ALS)
This trial uses a special MRI scan to help diagnose ALS by looking at signs in both nerve pathways. If you’re being evaluated for ALS, it may help doctors confirm the diagnosis sooner and more accurately.
ToulouseAges 18–99 - NCT04885374Recruiting
ALS patient registry for people using traditional Chinese medicine
This trial is a registry that collects information from adults with ALS who are using traditional Chinese medicine. It may help researchers better understand ALS and how traditional treatments are used alongside standard care.
BeijingAges 18 years+ - NCT05119387Recruiting
Genetic study for amyotrophic lateral sclerosis (ALS) in Norway
This study looks at genetic (inherited) factors in people with ALS. Your participation may help researchers better understand why ALS happens and who might be at risk.
BergenAges 16–100 - NCT05204017Recruiting
Study platform to better understand and treat ALS
This study uses a comprehensive analysis platform to better understand ALS (and related conditions) and help find ways to “remedy and eliminate” it. If you have ALS or are a healthy control who can safely complete questionnaires and possibly an MRI, you may be able to contribute data that researchers use to improve care.
Edmonton, AlbertaAges 18 years+
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Amyotrophic Lateral Sclerosis trials by city
Studies with a site in or near these metro areas.
Amyotrophic Lateral Sclerosis trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 190 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.