Preventing pancreatitis after endoscopic bile duct procedures
Part of Digestive system clinical trials.
This study tests whether combining a rectal anti-inflammatory medication (indomethacin) with cold water cooling of the pancreas opening during an endoscopic procedure can better prevent pancreatitis—a painful inflammation of the pancreas—compared to medication alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You need a standard medical reason for having an ERCP (endoscopic procedure to treat bile duct or pancreas issues)
- You cannot be pregnant or breastfeeding
- You cannot have chronic pancreatitis, pancreatic cancer, or acute pancreatitis in the past 2 weeks
- You cannot have severe kidney disease or active kidney injury
- You cannot have a history of rectal abnormalities or active bleeding problems
- You cannot be allergic to NSAIDs (anti-inflammatory drugs) or have severe liver disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether rinsing the pancreas with cold water during ERCP can reduce the risk of pancreatitis, a common complication. The treatment is added to the standard medicine (indomethacin) to see if it offers extra protection.
This Phase 3 study tests whether putting an anti-inflammatory medicine into the rectum (indomethacin) plus taking an immune-suppressing pill (tacrolimus) works better than using the two medicines in a different combination to prevent pancreatitis after an ERCP procedure. If you qualify, you may be assigned to one of the treatment options to lower your risk of post-ERCP pancreas inflammation.
This study tests whether a rectal suppository of indomethacin (a type of anti-inflammatory) can help prevent complications during a bile duct procedure called ERCP. It's for people who have already had a prior bile duct cut.
This study compares indomethacin (an anti-inflammatory medicine) against using a temporary pancreatic stent to prevent pancreatitis after an ERCP procedure. It may help you lower the chance of painful inflammation of the pancreas after ERCP.
This trial tests whether giving extra IV fluids before, during, and after an ERCP procedure can help prevent a common complication called post-ERCP pancreatitis (inflammation of the pancreas). If you are scheduled for an ERCP, you may be eligible to participate.
This trial tests whether flushing the bile duct opening with ice-cold water after a routine procedure can lower the risk of pancreatitis. It's for adults who are already scheduled for a sphincterotomy to help bile flow.
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