Medicine and ice water to prevent post-ERCP pancreatitis
Part of Digestive system clinical trials.
This study tests whether adding ice water irrigation to standard rectal indomethacin reduces the risk of inflammation of the pancreas after ERCP, a procedure that examines the bile and pancreatic ducts. It may help prevent a painful complication.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must be scheduled for an ERCP and have not had this procedure or a sphincterotomy (cutting the sphincter muscle) before.
- You must be able to receive the study medication (rectal indomethacin) and be willing to have follow-up blood tests.
- You cannot have active acute pancreatitis, chronic pancreatitis, or a blocked main pancreatic duct due to cancer.
- You must not be pregnant and must not have an allergy to indomethacin or other NSAID pain relievers.
- Your doctor must confirm that your papilla (the opening into the bile duct) is reachable during the procedure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests giving indomethacin (a type of anti-inflammatory medicine) through the rectum in different doses to people having an ERCP (a procedure to look at bile and pancreas tubes), aiming to prevent a common complication called post-ERCP pancreatitis (inflammation of the pancreas). You may join if you are at high risk for this complication and meet the other health requirements.
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