Nintedanib plus cough reliever for advanced lung scarring
Part of Lungs & breathing clinical trials.
This study tests whether adding a cough suppressant called dextromethorphan to the standard IPF medication nintedanib helps improve cough and lung function better than nintedanib alone. It is a 12-week treatment phase with a 1-week follow-up, designed for people with moderate IPF.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 40 years or older and have a clear diagnosis of IPF (a specific type of lung scarring).
- Have breathing tests that show moderate lung capacity: FVC at least 45% of normal, and DLco between 30% and 80% of normal.
- No IPF flare-ups (sudden worsening) in the last 3 months.
- If you're of childbearing age, you must have a negative pregnancy test and use effective birth control during the study and for 3 months after.
- Avoid certain other lung conditions (like COPD stage 3+, asthma, or drug-related lung disease).
- Be willing to stop nintedanib or pirfenidone for at least 8 weeks before starting the trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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