Clin2
NCT07599111Possibly a fitNot yet recruiting

Nebulized stem cell exosomes for immune checkpoint inhibitor-related pneumonitis

Pneumonitis, InterstitialImmune Checkpoint Inhibitors (ICIs)Mesenchymal Stem CellsExosomes

Treatments studied

Part of Lungs & breathing clinical trials.

This trial tests a new treatment for lung inflammation caused by cancer immunotherapy. You inhale a mist containing tiny particles from stem cells, which may help reduce the inflammation and improve your lungs.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
40 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are 18 to 75 years old and have a confirmed cancer diagnosis.
  • You have had lung inflammation from immunotherapy that is severe (grade 3 or 4) and has not fully resolved after at least 4 weeks of steroid treatment.
  • You are on a low dose of steroids or have stopped taking them.
  • Your cancer has been stable for at least 6 months, and you are able to do daily activities with little help.
  • You can inhale medication through a nebulizer and complete lung function tests.
  • You are not currently taking antifibrotic drugs like pirfenidone or nintedanib.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07570836Not yet recruiting· Phase 1
Stem cell particles for lung scarring

This study tests an experimental treatment using tiny particles from human stem cells, given through a nebulizer (breathing mist). It aims to see if this treatment is safe and can help improve lung function in people with interstitial lung disease (lung scarring).

Shanghai
NCT07441226Recruiting· Phase 2
Stem cells for advanced COPD treatment

This trial tests whether adding umbilical cord stem cells to standard triple therapy can help people with Group E COPD. It aims to see if this approach improves lung function and quality of life.

Jakarta, Jakarta Special Capital Region
NCT07554885Not yet recruiting
Nutritional supplement and steroids for lung inflammation from cancer treatment

This study tests whether adding a special nutritional supplement to the usual steroid treatment helps people recover from lung inflammation caused by cancer immunotherapy. If you have grade 3-4 immune-related pneumonitis, this trial may offer a way to improve your recovery.

Guangzhou, Guangdong
NCT06534528Not yet recruiting· Phase 1
Stem cell treatment for interstitial lung disease

This study tests whether a single injection of stem cells from umbilical cord blood can improve lung function in people with interstitial lung disease. It might help reduce inflammation or repair damaged lung tissue.

NCT07806045Not yet recruiting· Early Phase 1
Inhaled cell particles for lung disease in IgG4-related disease or scleroderma

This study tests a new treatment that is breathed in as a mist (nebulized) and uses tiny particles from cells (called extracellular vesicles) to help calm the immune system. It is for people with IgG4-related disease or systemic sclerosis that have lung problems, and may help reduce inflammation and improve breathing.

Beijing
NCT07103980Recruiting· Phase 1/Phase 2
Study of stem cell particles for cough after infection

This trial tests if inhaled particles from stem cells (called exosomes) can help with a cough that lasts 3-8 weeks after a cold or flu. It may be an option if your chest X-ray is normal and other causes of cough have been ruled out.

Shanghai, Shanghai Municipality

Hear when a new Immune Checkpoint Inhibitors (ICIs) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.