Switch to under-the-skin ocrelizumab for multiple sclerosis
Part of Brain & nervous system, Immune system & allergy clinical trials.
This trial tests a new way of taking Ocrelizumab as a shot under the skin, for people with MS who are already on a similar treatment and want to switch. The goal is to see if switching is safe and works well.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of relapsing MS or primary progressive MS (McDonald 2017 criteria).
- You are currently on an approved anti-CD20 therapy (Ocrevus, Kesimpta, or Briumvi) and your reason for switching is NOT that the drug stopped working or caused serious side effects like severe allergic reactions or frequent infections.
- Your disability level is mild to moderate (EDSS score between 0 and 6.5).
- You can have MRI scans and have no active or chronic infections (like HIV, tuberculosis, or hepatitis).
- You have not had a history of PML (a rare brain infection) or prior treatment with certain MS drugs (like cladribine, alemtuzumab, or mitoxantrone).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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