enVVe Valve System for Severe Leg Vein Disease
Part of Brain & nervous system, Eyes & vision clinical trials.
This trial tests a new implantable valve designed to treat severe leg swelling and skin damage caused by faulty deep veins that have stopped working properly. The valve may help prevent complications and improve symptoms after standard treatments haven't fully worked.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Leg symptoms that haven't improved after at least 3 months of standard care (compression stockings, pneumatic compression, and wound care if needed)
- Specific vein damage confirmed by ultrasound showing backward blood flow in the deep veins of your thigh and behind your knee
- Moderate to severe leg swelling, skin changes, or open wounds (CEAP score C4b, C4c, C5, or C6)
- Able to walk normally without assistance and stand still for imaging tests
- Able to attend all follow-up visits and take blood-thinning medications for at least 6 months to 5 years after the procedure
- No recent blood clots, active cancer, or major surgery within the past 2 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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