Psilocybin therapy for depression in Parkinson's disease
Treatments studied
Part of Brain & nervous system clinical trials.
This study tests whether psilocybin (a psychedelic compound) combined with therapy can reduce depression in people with Parkinson's disease. If you have moderate-to-severe depression and Parkinson's, this trial may offer a new treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have neurologist-diagnosed Parkinson's disease (early-to-moderate stages) that is currently controlled with medication
- You have moderate or severe depression (a specific screening test will confirm this)
- You are willing to avoid many common medications, supplements, and substances for specific periods before and after treatment sessions
- You have no serious psychiatric conditions like schizophrenia, bipolar disorder, or recent suicidal thoughts
- You have a primary care doctor or neurologist actively involved in your care who can consult with the study team
- You can understand English, provide informed consent, and commit to not changing your Parkinson's medications during the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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