Clin2
NCT07620496Possibly a fitNot yet recruiting

Testing an experimental drug for precancerous mouth lesions

Oral Epithelial Dysplasia (OED)

Part of Cancer, Mouth & dental clinical trials.

This study tests an experimental medication called CAN1012 for people with oral dysplasia, a pre-cancerous condition in the mouth. The goal is to see if it is safe and can help prevent the condition from becoming cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
36 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have oral dysplasia — a pre-cancerous condition in your mouth (white or red patches that may become cancer).
  • You are 18 years of age or older and able to give consent.
  • You are generally in good health and able to carry out daily activities (performance status 0–1).
  • Your blood counts and liver/kidney function need to be within acceptable ranges (checked within 72 hours before starting).
  • If you can become pregnant, you must agree to use effective birth control during treatment and for 165 days after the last dose.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07090070Recruiting
Treatment study for p53 mutant oral cancer and precancers

This trial tests different treatments for people with oral cancer or precancerous lesions that have a p53 mutation. It aims to find the best approach for early-stage disease to prevent progression.

Vancouver, British Columbia
NCT07408856Recruiting· Phase 1
A trial of CAN1012 for early breast changes (DCIS and LCIS)

This trial tests a new drug called CAN1012 in people with pre-cancerous breast conditions called DCIS or LCIS. It aims to see if the drug can help before invasive cancer develops.

Portland, Oregon
NCT05865028Recruiting· Phase 2
Test drug APG-157 for abnormal mouth tissue

This Phase 2 trial studies whether APG-157 can safely improve abnormal cells in the mouth (dysplasia) or early cancer-like changes (carcinoma in situ). You may be eligible if you have a visible, biopsy-proven lesion and can take oral medication while meeting blood and health requirements.

Miami, Florida
NCT07579507Not yet recruiting
Oral cancer development study for patients having surgery or precancerous mouth lesions

This study looks at how oral cancer develops, from early changes in the mouth to invasive cancer. It may help find better ways to prevent or treat oral cancer. If you are having surgery for oral cancer or have a precancerous mouth condition, you may be able to join.

Lyon
NCT06550050Recruiting
Study of Mouth Precancer and Cancer Features

This study looks at tissue and blood samples from people with mouth conditions that could become cancer or are already cancer. It aims to learn more about these conditions to improve diagnosis and treatment.

Houston, Texas
NCT07260344Recruiting
Testing two new ways to find early mouth precancer

This study compares two non-invasive methods to detect precancerous sores in the mouth. It aims to find a simpler way to catch early changes before they become cancer.

Taipei, Taipei

Hear when a new Oral Epithelial Dysplasia (OED) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.