Letrozole vs. Methotrexate for Early Ectopic Pregnancy
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This trial tests two medicines—letrozole and methotrexate—to see which works better for treating ectopic pregnancy (a pregnancy growing outside the uterus) without surgery. Both medicines may help your body safely end the pregnancy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have an ectopic pregnancy confirmed by transvaginal ultrasound (a vaginal ultrasound that shows the pregnancy is outside the uterus)
- You are between 20 and 35 years old
- Your hCG hormone level is below 3000 (a measure of pregnancy hormone in your blood)
- The ectopic pregnancy mass in your pelvis is 3.5 cm or smaller
- Your blood pressure and heart rate are stable and you are not in shock
- You have no fetal heartbeat, no history of allergic reactions to methotrexate or letrozole, and normal liver and kidney function
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether letrozole (a hormone-blocking pill) can treat an ectopic pregnancy safely and effectively, allowing you to keep your ability to have children. It is an alternative to methotrexate, and you'll be randomly assigned to one of the two treatments.
This study looks at using methotrexate (a medication) to treat ectopic pregnancy (a pregnancy outside the uterus) in women who have some health issues that might make the usual treatment riskier. It aims to see how well methotrexate works for them.
This study looks at how blood flow patterns around an ectopic pregnancy (pregnancy outside the uterus, in the fallopian tube) might predict whether medication or watchful waiting will work for you. Ectopic pregnancies cannot result in a baby and need treatment; this research aims to help doctors choose the best approach.
This trial compares two types of minimally invasive surgery for ectopic pregnancy to see which works better. Both procedures remove the fallopian tube and pregnancy without a large belly incision.
This trial compares giving methotrexate (a medicine that stops the pregnancy from growing) locally (injected near the pregnancy) versus systemically (as a shot in your muscle) to treat an ectopic pregnancy in the uterus. It aims to find which way is safer and works better, with fewer side effects.
This study compares two medications—letrozole plus misoprostol versus misoprostol alone—to see which is more effective for ending a pregnancy in the second trimester (14–20 weeks) after the fetus has stopped developing. The goal is to find a safer, more comfortable method for women who need this procedure.
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