Nerve Damage Prevention in Advanced Bladder Cancer Treatment
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This study watches for nerve damage (peripheral neuropathy) in patients receiving two cancer drugs—enfortumab vedotin and pembrolizumab—for advanced bladder cancer. Researchers will test whether a supportive medication called Neuridase can help prevent or reduce nerve pain and numbness that sometimes occurs with this treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older
- You have been diagnosed with advanced or metastatic urothelial carcinoma (a type of bladder cancer) confirmed by biopsy
- Your doctor plans to treat you with enfortumab vedotin and pembrolizumab as part of your regular cancer care
- You do not have severe nerve damage (peripheral neuropathy) already affecting your hands or feet
- You are not pregnant, breastfeeding, or allergic to the study medication Neuridase
- You are able to give written informed consent and participate in study visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether two drugs (enfortumab vedotin and pembrolizumab) given before surgery can help patients with muscle-invasive bladder cancer or upper-tract urothelial cancer. The goal is to shrink tumors and improve outcomes before surgery removes the cancer.
This study looks at how enfortumab vedotin, a cancer drug, affects the nerves. It aims to understand and track neuropathy (nerve damage) in people with urothelial carcinoma, so doctors can better manage side effects.
This study watches for nerve problems in people getting enfortumab vedotin and pembrolizumab as their first treatment for advanced bladder cancer. It aims to understand how common these side effects are and how they affect patients.
This study looks at whether enfortumab vedotin (EV) affects the nervous system in people with advanced bladder cancer. It follows patients who are getting EV (alone or with immunotherapy) to see how their nerve function changes over time.
This study tests whether adding acupuncture and exercise can help prevent or reduce nerve pain, numbness, or tingling caused by a cancer treatment called EV-Pembro (a drug combination for bladder cancer). It may help you stay active and feel better during treatment.
This trial tests a two-drug combination (pembrolizumab and enfortumab vedotin) followed by maintenance pembrolizumab for people with advanced bladder cancer that has not been treated before. The goal is to see if this approach helps control the cancer for longer.
Hear when a new Peripheral Nerve Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.