Testing RB1-negative Leiomyosarcoma Treatment with REC-617
Part of Cancer clinical trials.
This study tests a new drug called REC-617 in patients with a rare muscle cancer (leiomyosarcoma) that has spread or cannot be surgically removed. The drug targets cancer cells that lack a specific protein called RB1, and you must have already tried at least one other cancer treatment before joining.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Confirmed leiomyosarcoma diagnosis with RB1-negative status (determined by tissue biopsy)
- Cancer is metastatic (spread to other parts of body) or cannot be surgically removed
- At least one prior systemic therapy (chemotherapy, immunotherapy, or similar treatment)
- Age 18 or older with adequate organ function and life expectancy over 3 months
- Ability to swallow pills and commit to contraception for the study duration
- Tumor lesions accessible for biopsy (at least 2cm if only one lesion available)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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