Clin2
NCT07636798Possibly a fitRecruiting

Chemotherapy and immunotherapy combination for advanced bile duct cancer

Biliary Tract Cancer

Part of Cancer, Digestive system clinical trials.

This trial tests a combination of three treatments—chemotherapy delivered directly to the liver, plus two immunotherapy drugs—for advanced bile duct cancer that cannot be surgically removed. The goal is to see if this combination works better than standard treatment and is safe for patients.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
20 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • Diagnosed with bile duct cancer (confirmed by biopsy or cytology) that cannot be surgically removed
  • Never received chemotherapy or immunotherapy before (some prior surgery is okay)
  • Good overall health and able to perform daily activities with minimal help (ECOG 0–1)
  • At least one measurable tumor visible on imaging scans
  • Blood counts, liver function, and kidney function meet safety thresholds for chemotherapy
  • No current serious infections, autoimmune diseases, or recent heart problems

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07569679Recruiting· Phase 2
Combination Chemotherapy and Immunotherapy for Biliary Tract Cancer

This trial tests a combination of chemotherapy drugs given directly into the liver, combined with two immunotherapy/targeted therapy drugs, for people with advanced biliary tract cancer (cancer of the bile ducts or gallbladder). The goal is to shrink tumors and improve survival in patients who have not received prior chemotherapy.

Xi'an, Shaanxi
NCT07831993Recruiting· Phase 2
Immunotherapy with chemotherapy for advanced bile duct cancer

This trial tests a new combination of a drug that helps your immune system fight cancer, called sintilimab, along with chemotherapy. It is for people who have bile duct cancer or gallbladder cancer that has spread to other parts of the body and have not had treatment for this stage yet. The goal is to see if this combination helps shrink tumors or stops them from growing.

Nanjing, Jiangsu
NCT07797816Recruiting· Phase 2
Targeted drug combo with radiation for advanced bile duct cancer

This trial tests a combination of two chemotherapy drugs and an immunotherapy drug, followed by targeted radiation, in people with bile duct or gallbladder cancer that cannot be removed with surgery. The goal is to see if this approach can shrink tumors and improve outcomes.

Nanjing, Jiangsu
NCT06389500Not yet recruiting· Phase 2
Combination treatment for locally advanced biliary tract cancer

This trial tests a combination treatment for biliary tract cancer that is borderline resectable or locally advanced. It combines a chemotherapy infusions directly into the liver (HAIC) with an immunotherapy drug (adebrelimab) and a targeted therapy pill (lenvatinib), aiming to shrink the tumor enough to allow surgery.

NCT07432568Not yet recruiting· Phase 2
Combination therapy for advanced bile duct cancer

This trial tests a combination of drugs to treat advanced bile duct cancer that cannot be removed by surgery. The treatment may help shrink tumors and improve outcomes.

NCT06296563Recruiting· Phase 2
Testing adebrelimab, apatinib, and HAIC for bile duct cancer

This trial tests if adding a combination of immunotherapy (adebrelimab), a targeted drug (apatinib), and chemotherapy into the liver artery (HAIC) before and after surgery can help people with resectable intrahepatic cholangiocarcinoma (a type of bile duct cancer). The goal is to see if this approach improves outcomes.

Jinan, Shandong

Hear when a new Biliary Tract Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.