Aprepitant for same-day discharge after knee replacement
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests if aprepitant, a medicine to prevent nausea, helps people leave the hospital sooner after knee replacement surgery. The goal is to see if it makes same-day discharge easier and more comfortable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are having a planned (non-emergency) knee replacement on one knee.
- You are between 18 and 90 years old.
- Your health is stable (classified as ASA I, II, or III).
- You will receive spinal or epidural anesthesia (numbing from the waist down), not general anesthesia.
- You can take ondansetron and dexamethasone (medicines to prevent nausea).
- You can speak and understand English or Spanish.
- You are able to give consent and fill out surveys.
- You are not pregnant or breastfeeding.
- You do not have serious liver problems.
- You are not taking pimozide (a medicine for certain mental conditions).
- You do not have a bowel obstruction or other serious digestive blockage.
- You are not scheduled for a revision (repeat) knee replacement.
- You are not enrolled in another drug trial for knee replacement.
- You are not using medications to reverse opioid or sedative effects.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
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This trial compares total intravenous anesthesia (TIVA) with spinal anesthesia for people having a first-time total knee replacement who are expected to go home the same day. The goal is to see which method works better for recovery and comfort.
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This study tests whether aprepitant helps prevent nausea and vomiting after middle ear surgery. If you are having this type of surgery, you may be able to join to help see if this medication improves recovery.
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