IN10018 and dalpiciclib for progressive meningioma
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This trial tests a combination of two oral drugs, IN10018 and dalpiciclib, for people with progressive meningioma (a type of brain tumor) that has not responded to standard treatments. The goal is to see if this combination can help shrink or slow the tumor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have a type of meningioma that is either Grade 2, Grade 3, or a Grade 1 that has come back after treatment
- Standard treatments (surgery, radiation, or other drugs) have not worked or are not available for you
- It has been at least 6 months since you finished radiation therapy
- Your blood cell counts, liver, kidney, and other organ functions are within a certain range (your doctor will check)
- You have not had a FAK inhibitor or a CDK4/6 inhibitor (like palbociclib) before
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 trial studies cabozantinib, a targeted pill medicine, for meningioma that has come back or is getting worse after standard treatment like surgery or radiation. It aims to shrink tumors and slow progression when other options may have limited benefit.
This Phase 1 trial studies whether combining two targeted medicines—alpelisib and trametinib—can shrink or slow progressive meningiomas that have already been treated with standard surgery and radiation. If you qualify, you may help test a new treatment approach for tumors that keep growing.
This trial tests abemaciclib, a targeted medicine, to see if it can help people with newly diagnosed grade 3 meningioma after standard radiation treatment. It may help by slowing tumor growth or improving outcomes after initial therapy.
This trial tests a drug called Zanzalintinib for people with meningioma that has come back or grown despite past treatments. It aims to see if the drug can stop or slow tumor growth.
This study tests a new drug called JZP3507 for people with meningioma (a type of brain tumor, grades 2 or 3) that has come back or grown despite previous treatment. The goal is to see if this medication can slow or shrink the tumor.
This trial tests dalpiciclib together with hormone (endocrine) therapy in people with HR-positive, HER2-negative advanced breast cancer whose cancer has already responded poorly to a prior CDK4/6 inhibitor. It aims to see if this combination can better control the cancer after that earlier treatment has failed.
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