Testing pirfenidone for narrowing of the windpipe
Treatments studied
Part of Ear, nose & throat clinical trials.
This study tests a medication called pirfenidone to see if it is safe and tolerable for people with idiopathic subglottic stenosis, a condition where the windpipe narrows without a known cause. Taking this drug may help reduce the need for repeated procedures to open the airway.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 65 years old.
- You have a confirmed diagnosis of idiopathic subglottic stenosis (narrowing of your windpipe with no known cause).
- In the past year, you've had at least 2 airway widening procedures (dilations) or you receive steroid injections into the airway every 3 months.
- You are generally stable, with no current infections or active inflammation.
- Your liver and kidney function are within normal ranges (checked by blood tests).
- You are not smoking, not pregnant or breastfeeding, and willing to avoid pregnancy during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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