Clin2
NCT07661797Possibly a fitNot yet recruiting

Study of LNF2105 for advanced solid tumors

Patients With Advanced Solid Tumors

Part of Cancer clinical trials.

This trial tests an experimental drug (LNF2105) for people with advanced solid tumors that have stopped responding to standard treatment. The drug targets a protein called Nectin-4 on cancer cells, and participating could give you access to a new option while helping to evaluate its safety.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
294 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have an advanced solid tumor (like bladder, breast, lung, ovarian, uterine, or cervical cancer) that is no longer responding to standard treatments, or you cannot tolerate those treatments, or no standard treatment exists.
  • You can provide a tumor tissue sample or previous test results showing Nectin-4 levels.
  • You have at least one measurable tumor on CT or MRI (at least 1 cm in size) that has not been treated with radiation or has grown after radiation.
  • You are in reasonably good health (ECOG 0-1) and expected to live at least 3 more months.
  • You have adequate organ function and are not pregnant, breastfeeding, or planning pregnancy during the trial.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06226363Not yet recruiting· Phase 1
Study of a new drug for advanced cancer

This study tests an experimental drug (LNF1901) for people with advanced cancers that haven't responded to standard treatments. The goal is to see if it is safe and how well it works, and it might help control the cancer or shrink tumors.

NCT07101549Not yet recruiting· Phase 1
Modified immune cells for advanced solid tumors with nectin-4

This trial tests a new type of immunotherapy called Nectin-4-CART-IL18 for advanced solid tumors that express a specific protein called Nectin-4. It uses your own immune cells, modified to better attack and kill cancer cells, and aims to help when standard treatments have failed.

Shenzhen, Guangdong
NCT06752447Not yet recruiting· Phase 1
Study of LNF2007 for advanced solid tumors

This trial tests a new drug called LNF2007 that targets a specific protein (Claudin18.2) found on some advanced cancer cells. It aims to see if the drug is safe and can shrink tumors in people with stomach, pancreatic, or bile duct cancer that hasn't responded to other treatments.

NCT06265727Recruiting· Phase 1/Phase 2
Study of CRB-701 for solid tumors with nectin-4

This trial tests a new drug, CRB-701, for people with advanced solid tumors that have a protein called nectin-4 on their surface. It might be an option if other treatments have stopped working or are not available.

Birmingham, Alabama
NCT07455734Recruiting· Phase 1/Phase 2
Testing BNT3214 for advanced solid tumors

This trial tests an experimental drug, BNT3214, in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if BNT3214 is safe and helps shrink tumors.

Clayton
NCT06682780Recruiting· Phase 1/Phase 2
Testing LM-2417 for advanced solid tumors

This trial tests a new drug, LM-2417, for people with advanced solid tumors that have come back or not responded to treatment. The study will see if LM-2417 is safe and effective, possibly as a new option for those who have run out of standard therapies.

Shanghai, Shanghai Municipality

Hear when a new Patients With Advanced Solid Tumors trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.