Chemotherapy before bladder removal surgery for muscle-invasive bladder cancer
Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests giving chemotherapy before surgery to remove the bladder, to see if it can improve outcomes for patients with muscle-invasive bladder cancer. The treatment is personalized based on a lab test of your tumor cells, which may help make the therapy more effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have bladder cancer that has grown into the muscle layer of the bladder wall, but has not spread to other parts of the body.
- You are able to have surgery to remove your bladder, and your doctors expect you to live at least 18 months.
- Your kidneys are functioning well, with a measure of at least 60 mL/min, and you have overall good health (able to do daily activities without help).
- You have not had chemotherapy, immunotherapy, or other targeted treatments for your bladder cancer before.
- Your blood counts and liver function are within acceptable ranges, and your heart is pumping well (50% or more).
- You agree to provide tissue, urine, and blood samples for research purposes, and use effective birth control during the study and for 6 months after.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study looks at how well a standard chemotherapy given before surgery works for muscle-invasive bladder cancer. It aims to see if higher responses lead to better outcomes.
This trial tests a stronger chemotherapy regimen (gemcitabine and cisplatin) given before surgery to remove the bladder. The goal is to shrink the cancer and improve the chances of successful surgery.
This trial studies how well certain markers in bladder cancer tissue can predict which patients will respond to chemotherapy given before surgery. This may help doctors choose the best treatment for each patient in the future.
This trial tests if adding a special CT scan before bladder removal helps find muscle-invasive bladder cancer earlier. It includes people with different stages of bladder cancer who are planning to have their bladder removed.
This trial compares three standard treatments for muscle-invasive bladder cancer: bladder removal surgery, radiation combined with chemotherapy, or both. It aims to find which approach works best while preserving quality of life.
This study looks at how chemotherapy given before bladder removal surgery changes the immune environment around the tumor. The goal is to see if these changes can help predict how well the treatment works, which could lead to better personalized care.
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