Chemo before surgery for muscle-invasive bladder cancer
Treatments studied
Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests a dense schedule of two chemotherapy drugs (gemcitabine and cisplatin) given before bladder removal surgery. It aims to shrink the tumor and improve outcomes for people with bladder cancer that has grown into the muscle layer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have bladder cancer that has spread into the muscle layer (stage T2 to T4a) but not to distant organs (M0).
- You must be healthy enough for chemotherapy, especially your kidneys (creatinine clearance at least 60).
- You must be able to have bladder removal surgery after the chemo.
- You must be in good daily activity (ECOG 0 or 1).
- Your blood counts, liver, and kidney function must be within normal ranges.
- You cannot have had prior chemo or radiation for bladder cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial looks at whether giving chemotherapy before surgery helps people with muscle invasive bladder cancer live longer. It is for patients who haven't had surgery yet and whose cancer hasn't spread.
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