Chemotherapy before bladder surgery for muscle-invasive cancer
Treatments studied
Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests a stronger chemotherapy regimen (gemcitabine and cisplatin) given before surgery to remove the bladder. The goal is to shrink the cancer and improve the chances of successful surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a type of bladder cancer called urothelial carcinoma (also known as transitional cell carcinoma).
- Your cancer is at a stage where it has grown into the bladder muscle but has not spread to distant organs (stages T2 to T4a, N0-N1, M0).
- Your kidneys must be working well enough (creatinine clearance of 60 or higher) to safely receive the chemotherapy.
- You are physically fit (able to do light activity, ECOG 0 or 1) and have adequate blood, liver, and kidney function.
- You have not had previous chemotherapy or radiation for bladder cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies giving toripalimab (an immunotherapy) together with gemcitabine and cisplatin before bladder surgery. It aims to shrink locally advanced bladder cancer and make surgery more effective by using the immune system and chemotherapy together.
This study looks at how well MRI scans can detect bladder cancer after chemotherapy, before surgery to remove the bladder. It may help doctors know if the chemo is working.
This trial tests giving chemotherapy before surgery to remove the bladder, to see if it can improve outcomes for patients with muscle-invasive bladder cancer. The treatment is personalized based on a lab test of your tumor cells, which may help make the therapy more effective.
This Phase 3 trial studies giving cisplatin-based chemotherapy before surgery for certain newly diagnosed upper-urinary-tract urothelial cancers (kidney/ureter). It may help shrink the cancer and improve outcomes by treating microscopic disease earlier.
This study looks at whether giving chemotherapy before surgery helps people with muscle invasive bladder cancer live longer. It reviews the outcomes of patients who received this treatment to see if it improves survival.
This trial tests whether giving chemotherapy before surgery can improve outcomes for people with high-risk cancer in the upper urinary tract (the tubes that carry urine from the kidneys to the bladder). The chemotherapy is given before the standard surgery to remove the affected kidney and ureter.
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