Study of sperm problems linked to inherited genetic mutation
Part of Kidney & urinary clinical trials.
This study is investigating a specific genetic mutation in the MT-ND1 gene that can be passed from mother to son and may cause sperm production problems. It compares men with severe sperm issues to those with normal sperm production to understand the genetic cause.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a man with no known cause for your very low or absent sperm count (idiopathic non-obstructive azoospermia or cryptozoospermia).
- You are undergoing a testicular biopsy, sperm retrieval procedure, or related surgery as part of your care.
- You do not have any other known cause for your azoospermia, such as missing chromosomes, Y-chromosome deletions, testicular cancer, or past cancer treatments.
- You or your relatives may be asked to provide a DNA sample for genetic analysis if needed.
- You must be able to give informed consent and have complete medical records.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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