PET-guided cell therapy for advanced melanoma
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests a new way to guide treatment with your own immune cells (called TIL therapy) using a special PET scan to see which tumors might respond best. It aims to make the treatment more effective for people with advanced melanoma that has not responded to previous therapies.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stage 4 melanoma that cannot be removed by surgery or has spread.
- Your melanoma has worsened after at least one prior treatment, including a PD-1 inhibitor (like pembrolizumab or nivolumab).
- You have at least two tumors that can be surgically removed (each at least 1.5 cm) to make the cell therapy, and they have not been previously treated with radiation.
- You have at least one other measurable tumor that can be tracked during the study.
- You are 18 years or older and are generally able to perform daily activities (ECOG 0 or 1).
- You are eligible for treatment with AMTAGVI (lifileucel) as determined by your doctor.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a treatment that uses your own immune cells, called tumor-infiltrating lymphocytes (TILs), to fight melanoma. Some participants also get a drug called pembrolizumab. The goal is to see if this approach can shrink tumors.
This trial tests a new T-cell therapy made from your own tumor (TILs), genetically edited to remove the PD1 checkpoint blocker. It may help your immune system fight melanoma that has not responded to standard treatments like anti-PD1 therapy.
This trial tests a treatment made from your own immune cells (called tumor-infiltrating lymphocytes). The cells are taken from a tumor sample, multiplied in a lab, and given back to you to help fight the cancer. It's for people with melanoma that has not responded to standard immunotherapy.
This study tests whether a special PET scan can help doctors choose the best tumor spot to remove for TIL therapy, which uses your own immune cells to fight melanoma. It may improve treatment outcomes by selecting the most effective immune cells.
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