Plasma exchange for children with severe sepsis
Treatments studied
Part of Infections clinical trials.
This trial tests whether removing harmful substances from the blood (plasma exchange) can help children with severe infections that cause organ failure or very low blood pressure. If your child is in the hospital with severe sepsis or septic shock and is between 1 month and 18 years old, this treatment might be an option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child is between 1 month and 18 years old.
- Your child has been diagnosed with severe sepsis or septic shock by their doctor.
- Your child does not have a known bleeding disorder or uncontrolled bleeding.
- Your child does not have an end-stage chronic illness with a life expectancy of less than 3 months.
- Your child has not had plasma exchange during this same hospital stay.
- Your child can safely have a central line (a special IV placed in a large vein).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether plasma exchange (a procedure that cleans the blood) can help children with a severe form of autoimmune encephalitis—a condition where the immune system attacks the brain. It's for children who haven't gotten better with standard treatments like steroids or IVIG.
This study tests whether therapeutic plasma exchange (a procedure that removes and replaces blood plasma) can improve outcomes in ICU patients with septic shock that is not responding to standard medicines. It may help some people whose infection-related illness is causing failing organs.
This study looks back at kids aged 1–18 who had a treatment called therapeutic plasma exchange (TPE) in the pediatric kidney unit. TPE is a procedure that replaces the liquid part of the blood, which may help with certain kidney conditions.
This study tests whether a blood purification treatment can help children with severe sepsis (a life-threatening infection) by filtering their blood to remove harmful substances. It may help improve organ function and recovery.
This trial tests whether a higher volume of plasma exchange (cleaning the blood to remove toxins) works better than the standard amount for children with acute liver failure who are not improving with usual care.
This study tests whether adding plasma exchange (a blood-cleaning treatment) to usual care can improve outcomes for people with new septic shock. If you qualify, you may receive this treatment soon after septic shock is diagnosed to help your body recover.
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